July 2024, Volume 2, Issue 7

Author

Sama Rizvi, Stuti Shukla, Saurabh Singh and Somya Gupta

Abstract

Introduction: Allergic rhinitis, a common and often debilitating condition affecting millions globally, remains a challenge for clinicians and patients alike. As we venture into the realm of probiotics and allergic rhinitis, it becomes imperative to unravel the multifaceted ways in which these microorganisms may influence immune modulation, inflammation, and the overall balance of the microbiome. In this exploration, we navigate the microbial frontier, seeking to unravel the intricate connections between probiotics and the management of allergic rhinitis. Methods: This study employed a randomized controlled trial (RCT) design to investigate the effects of probiotics on allergic rhinitis symptoms. The trial adhered to CONSORT guidelines, ensuring robust methodological standards. Participants were recruited from allergy clinics and community health centres. Inclusion criteria encompassed individuals aged 18-65 years, diagnosed with allergic rhinitis, and not currently undergoing immunotherapy. Exclusion criteria included severe gastrointestinal disorders, antibiotic use within the past three months, and concurrent participation in other clinical trials. A total of 80 participants were enrolled. Results: The probiotic group demonstrated a significantly higher improvement rate, with 32 participants (80%) showing improved allergic rhinitis symptoms compared to 8 participants (20%) in the placebo group (p < 0.001). Conclusion: In conclusion, this RCT contributes compelling evidence supporting the use of probiotics in alleviating allergic rhinitis symptoms. The significant improvement observed, coupled with the favourable safety profile, positions probiotics as a promising complementary strategy.